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ROS are involved in the regulation of a wide range of physiological and pathological processes 15,16

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7 Conclusion and perspectives 7.1 Summary of key mechanisms The molecular mechanisms of macrophage polarization involve dynamic interactions among signaling networks, metabolic reprogramming, and epigenetic modifications, centered on the precise regulation of the balance between pro-inflammatory M1 and anti-inflammatory reparative M2 phenotypes

The SCFAs are the major metabolites produced by gut microbiota fermenting dietary fibers, proteins, and peptides

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